Involvement of tryptase-positive mast cells and angiogenesis in the growth of inflammatory odontogenic cysts

Inflammatory periapical lesions are characterized by infiltration of different immune cell types, the functions which depend on an effective vascular network. This study aimed to evaluate mast cells density (MCD) in inflamatory odontogenic cysts capsules concerning microvascular (MVD), area (MVA), and perimeter (MVP), correlate such findings with type lesion, intensity inflammatory infiltrate, thickness epithelial lining. Twenty dentigerous (IDCs), twenty radicular (RCs), residual (RRCs) were submitted immunohistochemical analysis using anti-tryptase anti-CD34 antibodies. RCs exhibited highest MCD, MVD, MVA, MVP indexes (p = < 0.001, p 0.008, 0.003 respectively), infiltrate grade III showed MVD 0.044). Considering thickness, a higher index was identified hyperplastic epithelium 0.018). In IDCs, RCs, RRCs, strong positive correlation observed between MVA (r 0.950 0.001; r 0.914 0.713 respectively). moderate MCD both 0.660 0.002; 0.634 0.003, These results suggest that tryptase-positive might play important role angiogenic activity while had indexes. Our also confirmed influence angiogenesis.